Endocrine Abstracts

Dynamic changes in gene expression patterns and cell behaviour are evident throughout embryonic and neonatal germ cell development in the mouse. In the testes, the postnatal period represents a time when the male germline stem cells (GSCs) or, gonocytes migrate to the basement membrane of the seminiferous tubules preparing for a lifetime of spermatogenesis and is an important area of study. Here we use the transgenic mouse that expresses green fluorescent protein under the Oct...

Introduction: LXRs are transcription factors that regulate cholesterol homeostasis and likely modulate other aspects of lipid metabolism. In the testis, tightly regulated lipid metabolism is crucial to maintain fertility. Testicular LXRs are highly expressed but their role in regulating lipid homeostasis is not fully understood. Lxrα/β double knockout male mice (Lxrα/β DKO) are sterile by 7 months of age, with aberrations in lipid...

Liver X receptors (LXRs) are are ligand-dependent transcription factors, members of the nuclear receptor superfamily of transcription factors. In humans two LXR isoforms exist, LXRα (NR1H3) and LXRβ (NR1H2). LXRα is expressed predominantly in metabolically active tissues, while LXRβ is expressed in the majority of tissues. They have long been known to have critical roles in regulation of lipid metabolism, particu...